Combine ground turkey, Worcestershire sauce, garlic powder, onion powder, salt and pepper in a large bowl; mix well.
1 ½ pounds ground turkey, 1 tablespoon Worcestershire sauce, 1 teaspoon garlic powder, 1 teaspoon minced onion, 1 teaspoon black pepper, 1 teaspoon kosher salt
Form 8, thin 4-inch wide patties. Place 4 on a work surface and top each with 4 quarters of cheese. Top them with the remaining 4 patties, pinching the edges to form a tight seal.
4 slices cheddar cheese
Preheat a cast iron skillet (or a grill) to medium heat. Cook burgers until well browned, 5-6 minutes on each side.
Serve with your favorite toppings on toasted hamburger buns.
4 hamburger buns, Lettuce, sliced tomato, sliced onions, pickles, or your favorite burger toppings